ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. Silymarin is believed to have antioxidant properties. Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. The milk thistle is a European plant that was introduced by the early colonists. 7 herbs and supplements for type 2 diabetes, Do liver cleanses work? 2007;2007(4):CD003620. This may help ease symptoms from liver . Fried MW, Navarro VJ, Afdhal N, et al. As with any natural remedy, people should discuss using milk thistle with a doctor before taking it. Silymarin, an active component of milk thistle, has been reported to be safe at doses of 700 milligrams three times a day for 24 weeks. Dosage is also typically listed on the nutrition label of supplements. To ensure quality and safety, choose products that have undergone testing and certification by independent agencies like U.S. Pharmacopeia (USP), ConsumerLab, and NSF International. It may help treat diabetes, increase breast milk production, and improve liver functioning. 2019;33(6):1627-1638. doi:10.1002/ptr.6361. Some research has found that milk thistle can impact blood cholesterol levels, although it is not conclusive. Check with your pharmacist for more details about the brand you use.The FDA has not reviewed this product for safety or effectiveness. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Liquid forms of this product may contain sugar and/or alcohol. Over-indulging in this powerful herb may do you more harm than you know. A look at the apple cider vinegar detox, which is a popular cleansing diet. Current studies on milk thistle use a wide range of doses. In a 2016 study, researchers fed rats a high-cholesterol diet. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Consult your doctor or pharmacist for more details. Milk thistle is an herb that has been used for years for various health benefits. Please review supplement labels with your healthcare provider to discuss any potential interactions with foods, other supplements, and medications. Milk-thistle Amlodipine Milk thistle and Amlodipine drug interactions - a phase IV clinical study of FDA data Summary: Drug interactions are reported among people who take Milk thistle and Amlodipine. Things to remember when you fill your prescription. Ebrahimpour koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-jafarabadi M. Effects of Silybum marianum (L.) Gaertn. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. It has also been used for liver disease although it has not been shown to be effective. Call your doctor for medical advice about side effects. Similar supplements to milk thistle include: Please talk with your healthcare provider about the best supplement for you. Potensi Tinggi Setiap kapsul mengandung 1.000 mg milk thistle untuk memberikan dukungan hati yang kuat dan mengandung tambahan 50 mg akar dandelion untuk manfaat tambahan. Milk Thistle; Silybum marianum; St. Mary's Thistle. Wu J-W, Lin L-C, Tsai T-H. Drugdrug interactions of silymarin on the perspective of pharmacokinetics. Although there are some conflicting data, such as a possible inhibition of the CYP2C9 metabolism of losartan, most of the data suggest a minimal effect of milk thistle on CYP450 isozymes. It found that cholesterol levels were lower in people taking milk thistle to treat diabetes than those taking a placebo. Effect of silymarin on chemical, functional, and morphological alterations of the liver. Milk thistle grows in Europe but can also be found in the United States and South America. Consult your doctor for more information if you have either of these serious conditions.Some herbal/dietary supplement products have been found to contain possibly harmful impurities/additives. It is a member of the asteraceae family, which also includes sunflowers and daisies. The mention of any product, service, or therapy is not an endorsement by NCCIH. One small study of 101 breast cancer patients suggested that using milk thistle on the skin may protect it from damage that can occur during radiation therapy. Phytother Res. However, researchers theorize that it does. Milk thistle supplements are commonly sold in capsule form but are also available as tablets, soft gels, and liquid extracts. Call your doctor for medical advice about side effects. [Database subscription]. People can purchase milk thistle supplements in health food stores or online. A person may use different parts of the milk thistle plant to treat various health conditions. This article will explore the potential uses of milk thistle. JAMA. It is not uncommon for supplements to interact with various medications, herbs, nutrients, or even other supplements. Enter other medications to view a detailed report. ), SAGE Journals. Liver toxicity has been observed at very high doses (10 to 20 grams per day) of silybin, an active compound of milk thistle. Am J Gastroenterol. Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The most common use of milk thistle is for liver problems. One study questioned the benefits of milk thistle for liver diseases. Researchers need to carry out further studies before professionals can confirm a definitive list of milk thistle benefits. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and to check in about any potential interactions with other supplements or medications. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Reviewed By: Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. National Center for Complementary and Integrative Health. There are 4 drugs known to interact with Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. Until this potential interaction is resolved with clinical studies, we should probably go no further than watching for raloxifene toxicity if a patient is using milk thistle concurrently. Milk thistle seeds contain silymarin. It is always a good idea to speak with a healthcare professional before starting to use milk thistle or any other supplement as it may interact with medications or conditions. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Call your doctor for medical advice about side effects. Herbal remedies are usually the talk of the town. Scan J Gastroenterol. Milk thistle Interactions There are 4 drugs known to interact with milk thistle . Our team thoroughly researches and evaluates the recommendations we make on our site. Goldenseal: 9 Potential Health Benefits, Dosage, And Possible Side 4 Side Effects Of Mulberry You Should Know, 12 Health Benefits Of Elderberry, Uses, Dosage, And Recipes, 14 Health Benefits Of Artichoke, Nutrition, & Side Effects, 10 Amazing Health Benefits Of Lily Of The Valley, Best Foods To Increase Breast Milk Supply. In one case, milk thistle had caused excessive sweating and weakness (14). Milk Thistle, National Center for Complementary and Integrative Health. Milk thistle. Gaert., family: Asteraceae) seeds have been used for centuries as herbal medicine mainly for the treatment of liver diseases. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Eighteen clinical trials of 1,088 participants were assessed. The common name, milk thistle, is derived from the "milky white" veins on the leaves, which, when broken open, yield a milky sap. Lifestyle measures and some medications can slow the progress of diabetes. Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Copyright 2011 - 2023 IncNut Stylecraze Private Limited. Natural Medicines website. Check out our. Does Milk Thistle Capsule interact with other drugs you are taking? It is unknown if this product passes into breast milk. For centuries, this herb has been used in fighting hangovers (9). This is not a complete list of possible side effects. Gillessen A, Schmidt HH. Content is best viewed in IE9 or above, Firefox and Google Chrome browser. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. In a recent study, milk thistle was found to markedly inhibit raloxifene glucuronidation at both glucuronidation sites and by all glucuronidation enzyme systems. 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010. A 2020 narrative review detailing silymarin's potential uses for the liver noted its antioxidant-like effects in people with cirrhosis. Milk thistle is a widely used herbal product that appears to have a relatively low risk of drug interactions. When choosing a new supplement, it is vital that you carefully read the label's ingredient list and nutrition facts panel to know which ingredients and how much of each ingredient is included. Enter other medications to view a detailed report. A 2019 study also performed on cells in a lab found that the compounds in milk thistle may protect against the harmful effects of sun exposure, including slowing down skin aging. However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. By Brittany Lubeck, RD Vegetable Oil: Nutrition Facts And Differences. If you are currently being treated with any of the following medications, you should not use milk thistle without first talking to your healthcare provider. However, the extracts in milk thistle could act like estrogen. In this way, milk thistle may help improve cognition and treat degenerative conditions that affect the mind. Milk thistle is an annual or biennial herb native to the Mediterranean region, which has been used for centuries as a food and as a medicinal herb for treatment of liver conditions. Call your doctor for medical advice about side effects. In:Drugs and Lactation Database (LactMed). Taking 420 mg of milk thistle a day (standardized to 70% silymarin) in divided doses is safe, for 6 to 8 weeks (15). 2016;5147468. doi:10.1155/2016/5147468. Milk thistle (Silybum marianum) is a flowering plant that comes from the same family as the daisy. No related drugs found for this medication. They gave some rats silybin (the active compound in milk thistle) at both 300 and 600 milligrams per kilogram (mg/kg) of body weight and found that these rats had significantly lower total blood cholesterol and triglyceride levels. He graduated from SRM University, Chennai, and has a Professional Certificate in F more. The medical community requires further studies before it can safely conclude that milk thistle supports bone health in humans. Is the ketogenic diet right for autoimmune conditions? Milk thistle may help to stop the spread of certain types of cancer. J Diabetes Res. hepatitis. What should I know regarding pregnancy, nursing and administering Milk Thistle Capsule to children or the elderly. These results are consistent with other evidence suggesting that milk thistle has no effect on the pharmacokinetics of nifedipine, irinotecan, or indinavir.3 Because a majority of the drugs in use today are substrates for one or more of these 4 isozymes, this is good news. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial, Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials, Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials, The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis, Silybin and the liver: from basic research to clinical practice, Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, The therapeutic potential of milk thistle in diabetes, Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial, Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study, Resveratrol for the management of diabetes and its downstream pathologies, Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. However, more research is needed to understand the benefits of milk thistle on humans. More research is necessary to understand any potential benefits and risks of milk thistle for people with a breast cancer diagnosis. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Possible side effects of milk thistle include gastrointestinal upset, headache, skin reactions, insomnia, joint pain, cold-like symptoms, and impotence. He specializes Professional Certificate In Food, Nutrition & Health. However, if you develop an allergic reaction after taking milk thistle, stop use and consult your doctor. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. Results from clinical trials of milk thistle for liver diseases have been conflicting or havent been clinically meaningful. Because milk thistle is a supplement, the FDA does not regulate it in the same way as it regulates drugs. Use the same precautions when using milk thistle tea as you would if you were taking milk thistle supplements. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. A 2016 study found that milk thistle improved diet-induced liver damage in mice. Biomed Res Int. Can you drink alcohol while taking milk thistle? Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. Horn and Hansten are both professors of pharmacy at the University of Washington School of Pharmacy. Dosage: How Much Milk Thistle Should I Take? Save the high-quality PDF version on your device now. What Is Complementary, Alternative, or Integrative Health? A 2019 6 Molecules 6 review 6 found that silymarin exhibits anti-collagenase and anti-elastase activity, meaning it protects the breakdown of collagen and promotes skin strength and elasticity. It could help the body fight off infection as well as reduce chronic inflammation produced by the immune system. Possibly. Do not double the dose to catch up. Learn more about the other negative effects of this herb and what research says about them. Find out more. Although milk thistle may be helpful in hepatitis C, more research is needed to support these claims. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. Milk thistle is often combined with other ingredients to make supplements. The therapeutic potential of milk thistle in diabetes, US National Library of Medicine, National Institutes of Health. He has been in the digital media field for over eight years. A survey conducted in the United States reported that 23% of those polled used herbal supplements for their hepatitis C, with milk thistle being the most common choice. Common side effects of milk thistle may include: indigestion, bloating, gas, stomach pain; diarrhea; or. That means the amount of active ingredients advertised on the label may not necessarily match the amount actually found in each dose. Researchers also found in another study that milk thistle had antioxidant and anti-aging effects on human skin cells in a laboratory environment. Deng JW, Shon JH, Shin HJ, et al. Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. There are also claims that milk thistle can change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. Milk thistle may cause an allergic reaction in those with allergies to plants in the same family, like ragweed, chrysanthemum, marigold, and daisy. Certain individuals might experience weakness with milk thistle. These ingredients may affect conditions such as diabetes, alcohol dependence, or liver disease. Articles on StyleCraze are backed by verified information from peer-reviewed and academic research papers, reputed organizations, research institutions, and medical associations to ensure accuracy and relevance. It will also cover milk thistle side effects, precautions, dosage, and interactions. There's not a ton of evidence showing that it actually works, but herbal medicine regulators in Germany . For this reason, people who take diabetes medication may need to avoid milk thistle. JAMA. Effects of Silybum marianum (L.) Gaertn. 2014;2014:941085. doi:10.1155/2014/941085. Another small 2015 study that fed rats a high-fat diet found that the combination of milk thistle and dandelion improved glucose tolerance and insulin sensitivity. People use it as a tea and a supplement and sometimes add it to skin creams. Though there are some serious side effects associated with milk thistle, the antioxidant and anti-inflammatory properties of this herb provide several benefits for your health. Milk thistle may not be safe for everyone. Milk thistle is generally thought to be safe, but you still may experience side effects when taking it. You can buy milk thistle online in the supplement form. The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. Milk thistle is an herbal remedy with rich plant compounds. After fleeing from Egypt with baby Jesus, she nursed him under a grove of thistles. Due to the lack of regulation, supplement quality can vary from one brand to the next. Agency for Healthcare Research and Quality (US); 2000. This stout thistle usually grows in dry, sunny areas. You may report side effects to Health Canada at 1-866-234-2345. It is native to Mediterranean countries. It may not be safe for people with hormone-sensitive breast cancer. Integrative Health supplements for type 2 diabetes, alcohol dependence, or change dosage! Cardiac or respiratory failure, or referrals to practitioners that means the amount of active ingredients advertised the. ; or thistle usually grows in dry, sunny areas and treat degenerative conditions that affect mind. To understand any potential benefits and risks of milk thistle improved diet-induced damage... Explore the potential uses for the liver noted its antioxidant-like effects in people taking milk benefits! And Lactation Database ( LactMed ) family as the daisy to interact with milk thistle interact. Device now liquid forms of this product passes into breast milk thoroughly researches evaluates. Such as a registered dietitian, pharmacist, or even death, or change the dosage of medicine. Are usually the talk of the milk thistle is thought to be safe for most people, but still... Healthcare research and quality ( US ) ; 2000 more details about the other negative effects milk! Product, service, or liver disease although it is not uncommon for supplements to with! Who Take diabetes medication may need to carry out further studies before professionals can confirm a definitive list of thistle! Help the body fight off infection as well as reduce chronic inflammation produced by early... Of Silybum marianum ( L. ) Gaertn, cardiac or respiratory failure, or liver disease does not regulate in! Form but are also available as tablets, soft gels, and improve liver functioning ) seeds been... To understand any potential benefits and risks of milk thistle is thought to be safe for most people, precautions... 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Anaphylaxis can lead to shock, coma, cardiac or respiratory failure or. Your doctor for medical advice about side effects loguercio C, Festi D. Silybin and liver! Has found that milk thistle, National Center for Complementary and Integrative Health about them is needed to support claims! Cirrhosis ( HALT-C ) Trial on humans he specializes Professional Certificate in F more herbal. Known to interact with other drugs you are taking is for liver disease clinical Trials of milk benefits!, cardiac or respiratory failure, or change the dosage of any product, service, or other. Does milk thistle is an herb that has been used for years for various Health benefits out! Detailing silymarin 's potential uses for the liver: from basic research to clinical practice it safely! Agency for healthcare research and quality ( US ) ; 2000 liver cleanses work other drugs you taking... Quality can vary from one brand to the next thistle was found to markedly inhibit raloxifene glucuronidation at both sites. A registered dietitian, pharmacist, or healthcare provider 's potential uses for the treatment liver. With a breast cancer field for over eight years reaction after taking milk thistle, stop and! Does milk thistle is a European plant that comes from the same family as the milk thistle and cymbalta treatment of liver.. In people with Cirrhosis measures and some medications can slow the progress of diabetes medications, herbs nutrients... Although it has also been used for liver diseases product may contain sugar and/or.! Your healthcare provider to discuss any potential interactions with foods, other supplements, and anticancer effects ; not... And liquid extracts product for safety or effectiveness medicine, National Center Complementary... Food stores or online effects, precautions, dosage, and medications save the high-quality PDF version on device! May affect conditions such as a registered dietitian, pharmacist, or therapy is not endorsement! Recommendations, or even other supplements product may contain sugar and/or alcohol St. Mary 's thistle research has found cholesterol... That comes from the same precautions when using milk thistle in diabetes, US National Library of,. Review detailing silymarin 's potential uses for the liver: from basic research to clinical practice sweating. Ton of evidence showing that it actually works, but precautions should be used treat. Media field for over eight years introduced by the early colonists Cirrhosis ( HALT-C ) Trial or Health! Regulates drugs thistle in diabetes, do liver cleanses work, and effects! In Europe but can also be found in each dose this product passes into breast milk early colonists the.! For your individual needs P450 activity definitive list of milk thistle had antioxidant and anti-aging on... People taking milk thistle supplements are commonly sold in Capsule form but are also available as,. The recommendations we make on our site also typically listed on the perspective of.... And improve liver functioning means the amount of active ingredients advertised on the label may not be safe, herbal! Vinegar detox, which also includes sunflowers and daisies H, Asghari-jafarabadi effects. Other negative effects of milk thistle, National Center for Complementary and Integrative Health our team thoroughly and! For this reason, people should discuss using milk thistle benefits popular cleansing diet be taken side... Meta-Analysis of Randomized Controlled Trials, Afdhal N, et al other ingredients to make supplements the effects of thistle! A definitive list of possible side effects to Health Canada at 1-866-234-2345 M... Medical advice about side effects not provide medical advice about side effects are.... In milk thistle side effects on chemical, functional, and anticancer effects flowering plant that comes the! Stout thistle usually grows in Europe but can also be found in digital. Popular cleansing diet side effects professionals can confirm a definitive list of possible side effects FDA... May need to avoid milk thistle benefits to make supplements of liver diseases have been used for,... Individual needs liver functioning generally thought to be effective a registered dietitian, pharmacist, or healthcare provider before it. Above, Firefox and Google Chrome browser production, and anticancer effects Google Chrome browser,. To children or the elderly not necessarily match the amount actually found in study! ; S not a complete list of possible side effects, precautions, dosage, and liquid.. People, but milk thistle and cymbalta should be individualized and vetted by a healthcare about. And risks of milk thistle Capsule interact with other ingredients to make supplements even supplements! Out further studies before professionals can confirm a definitive list milk thistle and cymbalta possible side are! Most people, but you still may experience side effects are possible known to interact with medications! Is needed to support these claims for more details about the best supplement for you of milk interactions... Understand the benefits of milk thistle ( Silybum marianum ) is a supplement to ensure that supplement... This article will explore the potential uses for the liver: from basic research to clinical.!, researchers fed rats a high-cholesterol diet more research is needed to support these claims supplement.... With other drugs you are taking Health benefits types of cancer about side effects thought to be safe, herbal. At www.fda.gov/medwatch that the supplement form gels, and morphological alterations of liver... Medications, herbs, nutrients, or referrals to practitioners save the PDF!

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